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KMID : 0043320060290070556
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Archives of Pharmacal Research
2006 Volume.29 No. 7 p.556 ~ p.562
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Structure-Activity Relationship Study of Asiatic Acid Derivatives for New Wound Healing Agent
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Jeong Byeong-Seon
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Abstract
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Ten semi-synthetic derivatives of asiatic acid were prepared and their wound healing effects were evaluated by employing a tensile strength assay and a wound area assay. Among them, ethoxymethyl 2-oxo-3,23-isopropylidene-asiatate (12) showed the strongest and the fastest wound healing activity. Furthermore, it left the smallest scar after healing.
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KEYWORD
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Asiatic acid, SAR, Wound healing
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